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Medically reviewed by Dr. Adrian Rawlinson
Written by our editorial team Last reviewed 31 January 2025
Type of medicine | Antibiotic |
Used for | Bacterial vaginosis |
Active ingredient(s) | Metronidazole |
Works by | Damaging the bacteria’s DNA, which stops the growth of bacteria |
Effective within | 5 days |
Available as | Vaginal gel and oral tablets |
Available strength(s) | 0.75% vaginal gel, 500mg oral tablets |
Usage | Gel: 1 applicatorful (5 grams), to be applied intravaginally, preferably at bedtime, for 5 consecutive days. Tablets: Take one tablet (500 mg) twice a day for 7 days. |
Is branded available? | Yes |
Storage | Store this medicine in the original packaging between 68°F to 77°F. |
Prescription required? | Yes, get it FREE with our online consultation. |
Who is suitable for an online consultation?** | Adult women suffering from bacterial vaginosis |
*Note: Our medical team must review your online consultation before approving this treatment. They will determine if the requested treatment and quantity are safe, appropriate, and effective for you.
Metronidazole vaginal gel is an antibiotic that is used to treat bacterial infections in your vagina, such as bacterial vaginosis (BV).
Metronidazole is the generic name of the medication, also available under the brand name Flagyl. Both the generic and brand-name versions have the same active ingredient and work in the same way.
The FDA approved Flagyl - the brand name for oral Metronidazole - in 1982. Metronidazole is available as a tablet, gel, and as an injectable under other brand names.
At SpeedyHealth, our doctors are able to prescribe Metronidazole tablets or gel for BV after you complete an online consultation.
This medication works by damaging the DNA of the bacteria that causes bacterial vaginosis. This stops the growth of bacteria in the vagina which treats the infection.
Did you know?
Metronidazole mainly targets the harmful bacteria causing the infection, but can also affect some of the good bacteria. However, your body will naturally restore the healthy balance of bacteria after your treatment is complete.
There are many benefits of using this medicine to treat BV:
The vaginal gel formulation offers targeted treatment as it is applied directly into the vagina. This means that there is little systemic absorption.
The vaginal gel is applied locally, which reduces the likelihood of experiencing systemic side effects compared to oral medicines. Also, since the gel acts in the vagina, it is less likely to disrupt your gut bacteria compared to oral antibiotics.
This gel is convenient to use as it is usually applied once daily at bedtime, making it easy for patients. The tablet is convenient to take and doesn’t involve an application process, like the gel.
The topical formulation means that there is less risk of interactions with other medications.
The tablets are usually prescribed for 7 days therefore, they won’t interfere with your lifestyle.
Metronidazole vaginal gel is effective in treating infections like bacterial vaginosis.
A clinical study compared the effectiveness of Metronidazole oral tablets with a placebo in 42 women with bacterial vaginosis. Women were either given Metronidazole 500 mg oral tablets three times a day for 10 days or a placebo.
The results showed that 76% of women were cured after taking Metronidazole tablets, compared to only 5% of women who took the placebo.
Metronidazole gel is also an effective treatment form for BV. In a clinical trial consisting of 53 women with BV, patients were allocated to receive treatment with 5g of Metronidazole gel or placebo for 5 days. The results showed that 87% of women who received Metronidazole were cured of BV compared with only 17% of those using the placebo.
This medicine is an effective option for many women however, it may not be suitable for everyone.
You can take Metronidazole if you are a woman over the age of 18 who has been diagnosed with bacterial vaginosis.
You should not use this medicine if you:
Speak to your doctor before taking this medicine if you have:
Speak to your healthcare professional if you are due to have blood tests as this medicine can interfere with the results of certain tests.
It's important to know when and how to take Metronidazole to effectively treat BV. This medicine won’t work as well if it is not taken correctly.
You may prefer using the vaginal gel if you want a localized treatment, which can reduce the risk of systemic side effects. This is also a good option if you do not want to take oral medication.
The tablets are suitable for those who prefer oral medication or find vaginal administration uncomfortable. They are also convenient and easy to administer.
Metronidazole dosage
Tablets: Take one tablet (500 mg) twice a day for 7 days. Space each dose at least 12 hours apart. For example, take the first dose at 8 AM and the next one at 8 PM.
Gel: One applicatorful (5 grams) of Metronidazole vaginal gel is to be applied inside the vagina, once daily for 5 consecutive days. Use this medicine at bedtime to reduce the likelihood of it leaking out during the day.
Method
Tablets: Swallow one tablet whole with a glass of water. Do not cut, crush, or chew the tablet.
Here are instructions on how to use Metronidazole vaginal gel: | |
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With or without food?
You can take the tablet with food or without food. But taking it with food can prevent an upset stomach.
If you have missed a dose of the tablet, take it as soon as you remember. If the missed dose is too close to your next dose, skip the missed dose and continue with the next dose. Do not take a double dose to make up for the missed dose.
If you miss applying a dose of the vaginal gel, use it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and stick to your regular dosing schedule. Do not use a double dose to make up for a missed dose.
This medicine begins to work as soon as you use the first dose. The highest levels of the medication in the body are reached 6 to 12 hours after application. You should notice an improvement in your symptoms within a few days and complete resolution within 5 days. If your infection worsens or symptoms don’t resolve, seek medical attention.
The tablets should be taken for a course of 7 days. The gel should be applied for 5 consecutive days to completely cure BV.
It’s important to make certain lifestyle changes to ensure this medicine is effective:
Limit sexual activity
Avoid sexual intercourse while using the gel to prevent irritation and ensure the treatment remains effective.
Maintain good hygiene
Keep the vaginal area clean and dry, but make sure to avoid douching or using scented products, as these can irritate the area and worsen symptoms.
Wear breathable underwear
Wear loose-fitting, cotton underwear to reduce moisture and prevent irritation.
Stay hydrated
Drink lots of water to reduce the risk of side effects like headaches.
Like all medicines, Metronidazole can cause some side effects.
Tablet | Gel |
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Tablet | Gel |
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For a full list of side effects, consult the patient information leaflet for the vaginal gel or tablets.
This medicine can interact with other prescription medicines, over-the-counter products, vitamins, and natural health supplements. These interactions may change how effective the treatment is.
This medicine may interact with the following:
This medicine may also interact with:
This is not a complete list of interactions. For a full list of drug interactions, visit drugs.com.
The safety information to follow when taking this medicine can be found in the table below:
Category | Safety | Advice |
---|---|---|
Alcohol | Avoid | Drinking alcohol whilst using this gel may make you feel or be sick, become confused, have a headache or an abnormally fast heart beat. |
Pregnancy | Consult your doctor | If you are pregnant or planning to become pregnant consult your doctor before using this medicine. |
Breastfeeding | Consult your doctor | This medicine passes into breast milk. Speak to your healthcare provider if you plan to breastfeed. |
Driving | Safe | This medicine doesn’t affect your ability to drive. |
Store this medicine in the original packaging between 68°F to 77°F. Ensure the medicine is kept out of reach of children and pets and away from direct sunlight.
Do not throw away any unused or expired gel in your household trash or flush it down your toilet. Take this medicine to your nearest pharmacy and ask them to dispose of it.
No, you cannot buy this medicine over the counter. You need a doctor’s prescription to purchase this medicine. This is because a doctor must first check to see if it is suitable for you based on your symptoms and medical history.
If you need a prescription, you can fill our consultation form, it is a quick and easy process. If one of our doctors approves of your prescription, you will receive it electronically.
Yes, you can buy Metronidazole 0.75% vaginal gel and Metronidazole 500mg tablets online from SpeedyHealth. All you have to do is:
Your privacy is our top priority. SpeedyHealth uses secure, encrypted transactions and complies with USA medical standards to maintain confidentiality.
Here’s why you should choose SpeedyHealth to manage your medicines easily:
The price of Metronidazole at SpeedyHealth includes everything you need:
At SpeedyHealth, this medicine starts at $39.99
Our pricing is transparent, with no hidden fees. Order today and benefit from our complete, all-inclusive service.
If this medicine is not right for you, good alternatives for treating BV are Clindamycin vaginal cream or Tinidazole tablets.
Feature | Metronidazole | Clindamycin | Tinidazole |
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Route | Gel (intravaginal) or Tablets (oral) | Cream (intravaginal) | Tablets (oral) |
Treatment duration |
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3 or 7 days | 5 days |
Usage |
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Apply 5g at bedtime | Take 1g once daily with food |
Effectiveness | 77% cure rate | 91% cure rate | |
Best for | Patients needing flexible options (oral or vaginal) | Patients preferring local treatment with fewer doses | Patients seeking simple, once-daily oral medication |
Pricing from | $39.99 | - | - |
Helene R , 30 Nov
Seems to be working just fine
Lucinda J , 25 Nov
Great!! Great!!! Great!!!
Debra S , 16 Nov
Works great !